Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives

Synthesis and Anticancer Activity of Novel Thiazole-5-Carboxamide Derivatives

A series of novel 2-phenyl-4-trifluoromethyl thiazole-5-carboxamide derivatives have been synthesized and evaluated for their anticancer activity against A-549, Bel7402, and HCT-8 cell lines. Among the tested compounds, highest activity (48%) was achieved with the 4-chloro-2-methylphenyl amido subst...

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Bibliographic Details
Main Authors: Wen-Xi Cai, Ai-Lin Liu, Zheng-Ming Li, Wei-Li Dong, Xing-Hai Liu, Na-Bo Sun
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Applied Sciences
Subjects:
thiazole
amide
synthesis
antitumour
Online Access:http://www.mdpi.com/2076-3417/6/1/8
Description
Summary:A series of novel 2-phenyl-4-trifluoromethyl thiazole-5-carboxamide derivatives have been synthesized and evaluated for their anticancer activity against A-549, Bel7402, and HCT-8 cell lines. Among the tested compounds, highest activity (48%) was achieved with the 4-chloro-2-methylphenyl amido substituted thiazole containing the 2-chlorophenyl group on the two position of the heterocyclic ring. Other structurally similar compounds displayed moderate activity. The key intermediates have been fully characterized.
ISSN:2076-3417

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