Cytotoxicity of Cultured Canine Primary Hepatocytes Exposed to Itraconazole Is Decreased by Pre-treatment With Glutathione

Cytotoxicity of Cultured Canine Primary Hepatocytes Exposed to Itraconazole Is Decreased by Pre-treatment With Glutathione

Objective: To identify the effect of glutathione (GSH) on cell survival in a novel in vitro model of itraconazole (ITZ)-associated hepatotoxicity using canine primary hepatocytes.Sample: Commercially sourced, cryopreserved male dog (Beagle) primary hepatocytes from a single donor.Procedures: Using a...

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Bibliographic Details
Main Authors:	Natalie M. Kirk, Miranda D. Vieson, Kim A. Selting, Jennifer M. Reinhart
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Veterinary Science
Subjects:	hepatocytes hepatotoxicity glutathione itraconazole canine
Online Access:	https://www.frontiersin.org/articles/10.3389/fvets.2021.621732/full

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