GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope

GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope

The strong links between (Human Leukocyte Antigen) HLA, infection and autoimmunity combine to implicate T-cells as primary triggers of autoimmune disease (AD). T-cell crossreactivity between microbially-derived peptides and self-peptides has been shown to break tolerance and trigger AD in experiment...

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Bibliographic Details
Main Authors: Thomas Whalley, Garry Dolton, Paul E. Brown, Aaron Wall, Linda Wooldridge, Hugo van den Berg, Anna Fuller, Jade R. Hopkins, Michael D. Crowther, Meriem Attaf, Robin R. Knight, David K. Cole, Mark Peakman, Andrew K. Sewell, Barbara Szomolay
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
T-cell receptor
peptide-HLA
insulin
molecular mimicry
general-purpose computing on graphics processing units (GP-GPU)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00296/full

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