Identification and Functional Characterization of Glycosylation of Recombinant Human Platelet-Derived Growth Factor-BB in Pichia pastoris.

Identification and Functional Characterization of Glycosylation of Recombinant Human Platelet-Derived Growth Factor-BB in Pichia pastoris.

Yeast Pichia pastoris is a widely used system for heterologous protein expression. However, post-translational modifications, especially glycosylation, usually impede pharmaceutical application of recombinant proteins because of unexpected alterations in protein structure and function. The aim of th...

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Bibliographic Details
Main Authors: Mengmeng Dai, Changming Yu, Ting Fang, Ling Fu, Jing Wang, Jun Zhang, Jun Ren, Junjie Xu, Xiaopeng Zhang, Wei Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4689512?pdf=render

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http://europepmc.org/articles/PMC4689512?pdf=render

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