Role of chemokines in the pathogenesis of rheumatoid synovitis

Chemokines play a central role in the pathogenesis of rheumatoid arthritis (RA) synovitis which is characterised by new blood vessel formation, thickening of the lining layer and infiltration of immune cells. The inflammatory infiltrate is generated by a series of events which include the recruitmen...

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Main Authors: F. Ingegnoli, A. Manzo, F. Fantini, R. Caporali, C. Montecucco, N. Pipitone, C. Pitzalis
Format: Article
Language:English
Published: PAGEPress Publications 2002-03-01
Series:Reumatismo
Online Access:https://reumatismo.org/index.php/reuma/article/view/52
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spelling doaj-1a856241759c430dad934e90faaf0fad2020-11-25T00:45:17ZengPAGEPress PublicationsReumatismo0048-74492240-26832002-03-0154110.4081/reumatismo.2002.12Role of chemokines in the pathogenesis of rheumatoid synovitisF. IngegnoliA. ManzoF. FantiniR. CaporaliC. MontecuccoN. PipitoneC. PitzalisChemokines play a central role in the pathogenesis of rheumatoid arthritis (RA) synovitis which is characterised by new blood vessel formation, thickening of the lining layer and infiltration of immune cells. The inflammatory infiltrate is generated by a series of events which include the recruitment of leukocytes from the blood stream into the tissue, their local retention and activation to effector cells. All these processes are finely regulated by the interplay of different cell adhesion molecules (CAMs) and chemoattractant factors called chemokines (CK). CK are a superfamily of small proteins that play a crucial role in immune and inflammatory reactions. These chemoattractant cytokines share structural similarities including four conserved cysteine residues which form disulphide bonds in the tertiary structure of the proteins. CK mediate their effects by binding specific receptors (CK-R) characterised by a domain structure which spans the cell membrane seven times and signal through heterotrimeric GPT-binding proteins. Activation of the CK network results in an amplification of the inflammatory cascade and consequently in the progressive destruction of RA joints. The recognition of the central role of CK in inflammation has paved the way to the development of new agents capable of interfering with CK and CK-R. This review will focus in particular on the role of CK in regulating leukocyte trafficking in RA joints.https://reumatismo.org/index.php/reuma/article/view/52
collection DOAJ
language English
format Article
sources DOAJ
author F. Ingegnoli
A. Manzo
F. Fantini
R. Caporali
C. Montecucco
N. Pipitone
C. Pitzalis
spellingShingle F. Ingegnoli
A. Manzo
F. Fantini
R. Caporali
C. Montecucco
N. Pipitone
C. Pitzalis
Role of chemokines in the pathogenesis of rheumatoid synovitis
Reumatismo
author_facet F. Ingegnoli
A. Manzo
F. Fantini
R. Caporali
C. Montecucco
N. Pipitone
C. Pitzalis
author_sort F. Ingegnoli
title Role of chemokines in the pathogenesis of rheumatoid synovitis
title_short Role of chemokines in the pathogenesis of rheumatoid synovitis
title_full Role of chemokines in the pathogenesis of rheumatoid synovitis
title_fullStr Role of chemokines in the pathogenesis of rheumatoid synovitis
title_full_unstemmed Role of chemokines in the pathogenesis of rheumatoid synovitis
title_sort role of chemokines in the pathogenesis of rheumatoid synovitis
publisher PAGEPress Publications
series Reumatismo
issn 0048-7449
2240-2683
publishDate 2002-03-01
description Chemokines play a central role in the pathogenesis of rheumatoid arthritis (RA) synovitis which is characterised by new blood vessel formation, thickening of the lining layer and infiltration of immune cells. The inflammatory infiltrate is generated by a series of events which include the recruitment of leukocytes from the blood stream into the tissue, their local retention and activation to effector cells. All these processes are finely regulated by the interplay of different cell adhesion molecules (CAMs) and chemoattractant factors called chemokines (CK). CK are a superfamily of small proteins that play a crucial role in immune and inflammatory reactions. These chemoattractant cytokines share structural similarities including four conserved cysteine residues which form disulphide bonds in the tertiary structure of the proteins. CK mediate their effects by binding specific receptors (CK-R) characterised by a domain structure which spans the cell membrane seven times and signal through heterotrimeric GPT-binding proteins. Activation of the CK network results in an amplification of the inflammatory cascade and consequently in the progressive destruction of RA joints. The recognition of the central role of CK in inflammation has paved the way to the development of new agents capable of interfering with CK and CK-R. This review will focus in particular on the role of CK in regulating leukocyte trafficking in RA joints.
url https://reumatismo.org/index.php/reuma/article/view/52
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