The dicyclohexylamine salt of RG108 (N-phthalyl-l-tryptophan), a potential epigenetic modulator

The dicyclohexylamine salt of RG108 (N-phthalyl-l-tryptophan), a potential epigenetic modulator

The dicyclohexylamine salt of RG108 (N-phthalyl-l-tryptophan) co-crystallizes with a water molecule and a disordered molecule of dimethylformamide (DMF), viz. dicyclohexylaminium (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoate dimethylformamide solvate monohydrate, C12H24N+&#183...

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Bibliographic Details
Main Authors: Johan Wouters, Anaelle Tilborg, Irving Boittiaux, Julie Braun, Didier Lambert
Format: Article
Language:English
Published: International Union of Crystallography 2010-12-01
Series:Acta Crystallographica Section E
Online Access:http://scripts.iucr.org/cgi-bin/paper?S160053681004626X
Description
Summary:The dicyclohexylamine salt of RG108 (N-phthalyl-l-tryptophan) co-crystallizes with a water molecule and a disordered molecule of dimethylformamide (DMF), viz. dicyclohexylaminium (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoate dimethylformamide solvate monohydrate, C12H24N+·C19H13N2O4−·C3H7NO·H2O. The conformation of the deprotonated compound is constrained by charge-assisted strong hydrogen bonds with the dicyclohexylaminium ion and a dense hydrogen-bond network involving co-crystallized solvent molecules. The dihedral angle between the fused ring systems in the anion is 58.35 (4)°.
ISSN:1600-5368

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