Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice

Dysregulated Gut Homeostasis Observed Prior to the Accumulation of the Brain Amyloid-β in Tg2576 Mice

Amyloid plaques in Alzheimer’s disease (AD) are associated with inflammation. Recent studies demonstrated the involvement of the gut in cerebral amyloid-beta (Aβ) pathogenesis; however, the mechanisms are still not well understood. We hypothesize that the gut bears the Aβ...

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Bibliographic Details
Main Authors: Pedram Honarpisheh, Caroline R. Reynolds, Maria P. Blasco Conesa, Jose F. Moruno Manchon, Nagireddy Putluri, Meenakshi B. Bhattacharjee, Akihiko Urayama, Louise D. McCullough, Bhanu P. Ganesh
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
gut-brain axis
neurodegenerative diseases
amyloid
alzheimer’s disease
tg2576
inflammatory cytokines
b12
tight junction proteins
gut integrity
Online Access:https://www.mdpi.com/1422-0067/21/5/1711

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