The effects of autologous platelet concentrate on the healing of intra-bony defects: a randomized clinical trial

• Main Authors: Nilofar Attar, Aashima Gupta, Nabeeh A. Alqahtani̇, Shahab Saquib Abullai̇s, Nitin Dani̇, Nitin Kudyar
• Format: Article
• Language: English
• Published: Istanbul University 2019-01-01
• Series: European Oral Research
• Subjects: intra-bony defects; periodontal regeneration; periodontitis; latelet rich plasma; β‑tricalcium phosphate
• Online Access: https://dergipark.org.tr/tr/pub/eor/issue/43439/529707
• ISSN: 2630-6158; 2651-2823

PurposeThe present study aimed to evaluate the clinical and radiographic effects ofautologous platelet concentrate (APC) on the healing of intra-bony defects filledwith β-tricalcium phosphate (β-TCP) and covered with collagen membranes.Subjects and methodsThis study included 30 defects of 14 systemically healthy subjects. All of them had,at least, two deep intra-bony, inter-proximal periodontal defects. Minimum probingpocket depth (PPD) was 6 mm. Clinical and imaging examination was performedboth at baseline and at 3, 6, and 9 months after surgery.ResultsBoth the test and control group revealed a significant reduction in all variableswhen compared with the base line. Mean reduction of the PPD in two groups ateach follow-up time point showed no significant difference. Means of the clinicalattachment gain of the same groups were significantly different (p<0.05). Meangingival recession at 3 month was not significant. However, the means of gingivalrecession coverage of two groups were significantly different at 6 and 9 months(p<0.05 for both).ConclusionSites treated with APC are more likely to demonstrate more clinical attachment gainand recession coverage at the end of 9 month compared to those without APC.