Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives

Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives

In this research, we exploited derivatives of thieno[2,3-b]pyridine as dual inhibitors of the key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) and 5-lipoxygensase (5-LOX). Testing these compounds in a rat paw oedema model revealed potency higher than ibuprofen. The most...

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Bibliographic Details
Main Authors:	Mosaad S. Mohamed, Yara E. Mansour, Hatem K. Amin, Moustafa E. El-Araby
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	Anti-inflammatory COX-2 5-LOX COX-1 thieno[2,3-b]pyridine
Online Access:	http://dx.doi.org/10.1080/14756366.2018.1457657

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