Abstract OR-21: 3D Structure of the Natural Tetrameric Form of Human Butyryl-cholinesterase as Revealed by Cryo-EM, MD and SAXS

Abstract OR-21: 3D Structure of the Natural Tetrameric Form of Human Butyryl-cholinesterase as Revealed by Cryo-EM, MD and SAXS

Background: Human plasma butyrylcholinesterase (hBChE, EC 3.1.1.8) is an endogenous bioscavenger that hydrolyzes numerous medicamentous and poisonous esters and scavenges potent organophosphorus nerve agents. Thus, the hBChE can be used to protect acetylcholinesterase as well as a marker for diagnos...

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Bibliographic Details
Main Authors: Konstantin M. Boyko, Timur N. Baymukhametov, Yury M. Chesnokov, Michael Hons, Sofya V. Lushchekina, Alexey V. Lipkin, Vladimir O. Popov, Michail V. Kovalchuk
Format: Article
Language:English
Published: International Medical Research and Development Corporation 2019-06-01
Series:International Journal of Biomedicine
Subjects:
butyrylcholinesterase
tetramer
cryo-EM
bioscavenger
Online Access:http://ijbm.org/articles/IJBM_2019_9_S1_OR21.pdf

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