Immunomodulatory Effects of Perioperative Dexmedetomidine in Ovarian Cancer: An In Vitro and Xenograft Mouse Model Study

Immunomodulatory Effects of Perioperative Dexmedetomidine in Ovarian Cancer: An In Vitro and Xenograft Mouse Model Study

BackgroundThe surgical stress response (SSR) causes immunosuppression which may cause residual tumor growth and micrometastasis after cancer surgery. We investigated whether dexmedetomidine affects cancer cell behavior and immune function in an ovarian cancer xenograft mouse model.MethodsThe effect...

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Bibliographic Details
Main Authors: Seokyung Shin, Ki Jun Kim, Hye Jeong Hwang, Sewon Noh, Ju Eun Oh, Young-Chul Yoo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Oncology
Subjects:
dexmedetomidine
immunomodulation
ovarian cancer
surgical stress response
sympathetic nervous system
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.722743/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.722743/full

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