The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway.

The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway.

Mutations in AIPL1 cause the inherited blindness Leber congenital amaurosis (LCA). AIPL1 has previously been shown to interact with NUB1, which facilitates the proteasomal degradation of proteins modified with the ubiquitin-like protein FAT10. Here we report that AIPL1 binds non-covalently to free F...

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Bibliographic Details
Main Authors: John S Bett, Naheed Kanuga, Emma Richet, Gunter Schmidtke, Marcus Groettrup, Michael E Cheetham, Jacqueline van der Spuy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22347407/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22347407/pdf/?tool=EBI

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