The Enhancing Effects of Peptidase Inhibitors on the Antinociceptive Action of [Met5]Enkephalin-Arg6-Phe7 in Rats
Previous in vitro studies have shown that the degradation of [Met5]enkephalin-Arg6-Phe7 during incubation with cerebral membrane preparations is largely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon. The present in vivo study shows that the inhibitory...
Main Authors: | Shigeru Takahashi, Xing Lu Jin, Kenya Kosaka, Masanobu Yoshikawa, Hiroyuki Kobayashi, Tetsuo Oka |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2007-01-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319342239 |
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