Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury

Body cavity macrophages reside on the serous surfaces of organs and believed to participate in organ repair following injury. Here the authors show with a fate-mapping reporter system that these cells, although accumulate at the surfaces of injured liver or lung, don’t penetrate deeply into the tiss...

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Bibliographic Details
Main Authors: Hengwei Jin, Kuo Liu, Juan Tang, Xiuzhen Huang, Haixiao Wang, Qianyu Zhang, Huan Zhu, Yan Li, Wenjuan Pu, Huan Zhao, Lingjuan He, Yi Li, Shaohua Zhang, Zhenqian Zhang, Yufei Zhao, Yanqing Qin, Stefan Pflanz, Karim E. I. Kasmi, Weiyi Zhang, Zhaoyuan Liu, Florent Ginhoux, Yong Ji, Ben He, Lixin Wang, Bin Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23197-7
Description
Summary:Body cavity macrophages reside on the serous surfaces of organs and believed to participate in organ repair following injury. Here the authors show with a fate-mapping reporter system that these cells, although accumulate at the surfaces of injured liver or lung, don’t penetrate deeply into the tissue.
ISSN:2041-1723