Alendronato de sódio: metodologias para análise quantitativa Sodium alendronate: methods for analytical quantitation

• Main Authors: Ana Ferreira Ribeiro, Nadia Maria Volpato
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2005-10-01
• Series: Química Nova
• Subjects: sodium alendronate; HPLC analysis; derivatization
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000500024

<abstract language="eng">This paper presents a review of some published proposals for the analysis of sodium alendronate. The drug is an aminobisphosphonate compound used to inhibit the osteoclastic resorption of bone, and different methods were developed for its quantitative determination. These methodologies employed reversed-phase or ion-exchange HPLC analysis, both associated with different detectors: UV and fluorescence detection after derivatization of the drug, conductivity and refractive index detectors, as well as the indirect UV detection. Titrimetry and spectrophotometry (with previous complexation of the drug), which are simpler procedures, were also described, but they showed poor specificity when compared to liquid chromatography.