Docetaxel Retinopathy: A Case Report

• Main Authors: Sylvia Nghiem-Buffet, Salomon Yves Cohen, Audrey Giocanti-Auregan
• Format: Article
• Language: English
• Published: Karger Publishers 2017-01-01
• Series: Case Reports in Ophthalmology
• Subjects: Taxanes; Tamoxifen; Toxic retinopathy; En-face OCT; Macular edema
• Online Access: http://www.karger.com/Article/FullText/455088

Background: To report the use of En-face optical coherence tomography (OCT) in a patient treated with docetaxel and tamoxifen for breast cancer for the detection of macular edema (ME) without evidence of leakage on fluorescein angiography (FA). Case Presentation: A 52-year-old woman treated for breast cancer presented with bilateral visual loss for 2 months. FA showed no significant leakage while spectral-domain OCT scans of both eyes showed foveolar and parafoveolar cystic spaces in a moderately thickened macula. En-face OCT segmented at the inner retina showed the petaloid arrangement of cystic cavities, comparable to a cystoid ME. Conclusions: The combined use of tamoxifen could have potentiated the toxic effect of docetaxel on the macula. En-face OCT images may reveal a petaloid aspect of the macula due to cysts in the inner retina segmentation, when FA shows no leakage.