Alterations in EGF-Endocytosis, Lysosomal Enzyme Transport and Maturation of Cathepsins in Juvenile Neuronal Ceroid Lipofuscinosis Fibroblasts

Alterations in EGF-Endocytosis, Lysosomal Enzyme Transport and Maturation of Cathepsins in Juvenile Neuronal Ceroid Lipofuscinosis Fibroblasts

Background: Juvenile neuronal ceroid lipofuscinosis (JNCL), one of the most frequent forms of the NCL storage diseases, is known to be caused by loss-of-function mutations in ceroid-lipofuscinosis neuronal protein 3 (CLN3), but its cell function has not been fully elucidated. We previously reported...

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Bibliographic Details
Main Author: Jaime Cárcel-Trullols
Format: Article
Language:English
Published: Shahid Beheshti University of Medical Sciences 2020-01-01
Series:International Clinical Neuroscience Journal
Subjects:
juvenile neuronal ceroid lipofuscinosis
lysosomal ph
clathrin mediated endocytosis
caveolae-mediated endocytosis
cathepsin l
cathepsin d
ci-mpr (ci-mpr)
retromer
epidermal growth factor receptor
Online Access:http://journals.sbmu.ac.ir/Neuroscience/article/download/27158/2

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http://journals.sbmu.ac.ir/Neuroscience/article/download/27158/2

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