Potential of Mimosa pudica leaf in the treatment of ulcerative colitis in rat

• Main Authors: Bharati Zaware, Ritu Gilhotra, Sanjay Ravindra Chaudhari
• Format: Article
• Language: English
• Published: Bangladesh Pharmacological Society 2018-08-01
• Series: Bangladesh Journal of Pharmacology
• Subjects: Mimosa pudica; Myeloperoxidase; Malondialdehyde activity; colitis.
• Online Access: https://www.banglajol.info/index.php/BJP/article/view/35648

The aim of present investigation was to validate its folk use in the treatment of ulcerative colitis in the rat model. Sprague Dawley rats were divided into nine groups with six animals in each group. The rats received seven days of pretreatment with chloroform, ethyl acetate or ethanolic extract of Mimosa pudica. For induction of ulcerative colitis, rats were administered with 2 mL of 4% acetic acid solution intrarectally. Ulcer index, macroscopical study of the colon, myeloperoxidase and malondialdehyde levels in colon tissue and blood, and histopathology of the colon tissue were studied. Intrarectal instillation of acetic acid caused increased ulcer index, colonic myeloperoxidase and malondialdehyde. Pretreatment with M. pudica ethanolic extract (400 mg/kg) significantly lowered the ulcer index, colonic myeloperoxidase and malondialdehyde as compared with the standard drug prednisolone. The present investigation demonstrates that the ethanol extract of M. pudica leaf is effective in the treatment of ulcerative colitis. Video Clip of Methodology: Embedding or block making: 24 sec   Full Screen   Alternate Tissue processing: 19 sec   Full Screen   Alternate Section cutting: 33 sec   Full Screen   Alternate