Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation

Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation

<i>Background</i>: Contextual fear conditioning (CFC) is a rodent model that induces a high and long-lasting level of conditioning associated with traumatic memory formation; this behavioral paradigm resembles many characteristics of posttraumatic stress disorder (PSTD). Chemokines (chem...

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Bibliographic Details
Main Authors: José Joaquín Merino, Vilma Muñetón-Gomez, César Muñetón-Gómez, María Ángeles Pérez-Izquierdo, María Loscertales, Adolfo Toledano Gasca
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
post traumatic stress disorder
ccr5/rantes chemokines
neural plasticity
chronic stress restraint
fear learning
neuro repair
neuroinmunology
neuroimmunomodulation
Online Access:https://www.mdpi.com/2218-273X/10/2/212

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