Cotinine halts the advance of Alzheimer’s disease-like pathology and associated depressive-like behavior in Tg6799 mice

Cotinine halts the advance of Alzheimer’s disease-like pathology and associated depressive-like behavior in Tg6799 mice

Alzheimer’s disease (AD) is associated with cognitive and non-cognitive symptoms for which there are currently no effective therapies. We have previously reported that cotinine, a natural product obtained from tobacco leaves, prevented memory loss and diminished amyloid-β (Aβ) plaque pathology in t...

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Bibliographic Details
Main Authors: Sagar ePatel, J Alex Grizzell, Rosalee eHolmes, Ross eZeitlin, Rosalynn eSolomon, Thomas Lee Sutton, Adeeb eRohani, Laura eCharry, Alexandre eIarkov, Takashi eMori, Valentina eEcheverria Moran
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Cotinine
Depression
Akt
memory loss
Alzheimer’s disease
protein kinase B
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00162/full

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