Study of D/G Hemoglobin incidence in a sample population (single institution)

• Main Authors: Kh Arjmandi, M Faranoush, Gh Bahoush, P Vossough, AA Hedayatiasl, Sh Ansari, E Shahgholi
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2005-03-01
• Series: International Journal of Hematology-Oncology and Stem Cell Research
• Subjects: Hemoglobin D/G; Hemoglobinopathis; Iran
• Online Access: https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/178

Background:  The hemoglobin disorders constitute the most prevalent group of monogenic disease A findings consis¬tent with this is a hemoglobin/G variant indicating that the patient has HbD/G trait. Hb D/G traits are clinically benign. In this study, the epidemiology of HbD/G was reviewed in a single institution in Iran. Methods and Materials: We conducted the epidemiological study at Aliasghar children's hospital and all patients with HbD/G were entered to this study. The hematological values, hemoglobin electrophoresis, peripheral blood smear and clinical findings were collected in the data special form. Results:  Among 11825 hemoglobin analysis performed, we detected 101 cases of hemoglobin D/G. There were 55.4% male and 44.6% female, median age 9±13.36 yrs. Homozygous of D/G was found in seven pa¬tients with splenomegaly, jaundice, mild anemia and Reticulocytosis. Heterozygote patients were as¬ymptomatic. There wasn't any correlation between HbD/G with serum ferritin, MCV, Hb and sex. Conclusion: In Iran HbD/G is relatively benign condition with mild anemia, Poikylocytosis and minimal hemolysis.