Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

Summary: Parkinson's disease (PD) is a complex and highly variable neurodegenerative disease. Familial PD is caused by mutations in several genes with diverse and mostly unknown functions. It is unclear how dysregulation of these genes results in the relatively selective death of nigral dopamin...

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Main Authors: Tim Ahfeldt, Alban Ordureau, Christina Bell, Lily Sarrafha, Chicheng Sun, Silvia Piccinotti, Tobias Grass, Gustavo M. Parfitt, Joao A. Paulo, Fumiki Yanagawa, Takayuki Uozumi, Yasujiro Kiyota, J. Wade Harper, Lee L. Rubin
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119304448

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