EWI-2 Inhibits Cell–Cell Fusion at the HIV-1 Virological Presynapse

EWI-2 Inhibits Cell–Cell Fusion at the HIV-1 Virological Presynapse

Cell-to-cell transfer of virus particles at the Env-dependent virological synapse (VS) is a highly efficient mode of HIV-1 transmission. While cell−cell fusion could be triggered at the VS, leading to the formation of syncytia and preventing exponential growth of the infected cell populati...

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Bibliographic Details
Main Authors: Emily E. Whitaker, Nicholas J. Matheson, Sarah Perlee, Phillip B. Munson, Menelaos Symeonides, Markus Thali
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Viruses
Subjects:
ewi-2
igsf8
tetraspanin
hiv
cell–cell fusion
virological synapse
t cell
syncytia
Online Access:https://www.mdpi.com/1999-4915/11/12/1082

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