Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach

Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach

Although it is recognized that cadmium (Cd) causes renal tubular dysfunction, the mechanism of Cd-induced nephrotoxicity is not yet fully understood. Mode of action (MOA) is a developing tool for chemical risk assessment. To establish the mechanistic MOA of Cd-induced renal tubular dysfunction, the...

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Bibliographic Details
Main Authors: Yangchun Zhang, Ziqi Liu, Qianmei He, Fei Wu, Yongmei Xiao, Wen Chen, Yuan Jin, Dianke Yu, Qing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Genetics
Subjects:
cadmium
mode of action
renal tubular dysfunction
pathway analysis
weight of evidence
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.696892/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.696892/full

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