Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules

Human induced pluripotent stem cells (hiPSCs) are powerful tools for modeling human brain development and treating neurodegenerative diseases. Here we established a robust protocol with high scalability for generating striatal medium spiny neurons (MSNs) from hiPSCs using small molecules under two-...

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Bibliographic Details
Main Authors: Naoya Amimoto, Kaneyasu Nishimura, Shun Shimohama, Kazuyuki Takata
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Stem Cell Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121003330