| Summary: | Cryogen spray cooling (CSC) could be applied clinically for the laser therapy of Ota’s nevus, a dermal hyperplastic pigmented disease with a morbidity rate of 0.1–0.6% in the Asian population. An accurate, efficient, complete simulation system that considers the entire spray cooling process, including cryogen flow in the tube nozzle, spray dynamics and internal phase change heat transfer (cold injury) in skin tissue, was established to determine suitable cryogen and cooling parameters. The optimum spray distances for R134a, R404A and R32 were determined to be 66.0, 43.1 and 22.5 mm, respectively. The corresponding maximum surface heat fluxes were 363.5, 459.9, and 603.6 kW∙m<sup>−2</sup>, respectively. The maximum surface heat flux of R32 with small spray distance was 1.66 times as large as that of R134a, indicating the potentially good cooling performance and precise targeted cooling of R32 during the laser therapy of Ota’s nevus. The cooling durations that caused cold injury of skin tissue were 2.3, 1.4, and 1.1 s for R134a, R404A, and R32, respectively. The interval between CSC and laser irradiation was optimized to 90–162 ms for R134a, R404A and R32, in consideration of the cooling effect, depth, uniformity, and risk of cold injury.
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