Inhibition of USP14 Deubiquitinating Activity as a Potential Therapy for Tumors with p53 Deficiency

Inhibition of USP14 Deubiquitinating Activity as a Potential Therapy for Tumors with p53 Deficiency

Functional elimination of p53 is a common feature of a large percentage of human malignancies. Here, we report the development of a pharmacological strategy aimed at restoring p53 function and its use for targeted therapy in p53-deficient mice. Specific inhibition of deubiquitinases ubiquitin-specif...

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Bibliographic Details
Main Authors: Yu-Shui Ma, Xiao-Feng Wang, Yun-Jie Zhang, Pei Luo, Hui-Deng Long, Liu Li, Hui-Qiong Yang, Ru-Ting Xie, Cheng-You Jia, Gai-Xia Lu, Zheng-Yan Chang, Jia-Jia Zhang, Shao-Bo Xue, Zhong-Wei Lv, Fei Yu, Qing Xia, Da Fu
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S237277052030005X

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