Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia.

Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia.

The presence of the Philadelphia chromosome in patients with acute lymphoblastic leukemia (Ph(+)ALL) is a negative prognostic indicator. Tyrosine kinase inhibitors (TKI) that target BCR/ABL, such as imatinib, have improved treatment of Ph(+)ALL and are generally incorporated into induction regimens....

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Bibliographic Details
Main Authors: Mary E Irwin, Laura D Nelson, Janice M Santiago-O'Farrill, Phillip D Knouse, Claudia P Miller, Shana L Palla, Doris R Siwak, Gordon B Mills, Zeev Estrov, Shulin Li, Steven M Kornblau, Dennis P Hughes, Joya Chandra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3731286?pdf=render

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