Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases

Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases

We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmap...

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Main Authors: Valeria Muller, Ksenia Ob’edkova, Inna Krikheli, Igor Kogan, Irina Fedorova, Elena Lesik, Evgenia Komarova, Alexandr Gzgzyan
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Case Reports in Immunology
Online Access:http://dx.doi.org/10.1155/2016/4391537
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spelling doaj-19cfa272685c4d57b5a52053eb65e0b12020-11-25T01:03:41ZengHindawi LimitedCase Reports in Immunology2090-66092090-66172016-01-01201610.1155/2016/43915374391537Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three CasesValeria Muller0Ksenia Ob’edkova1Inna Krikheli2Igor Kogan3Irina Fedorova4Elena Lesik5Evgenia Komarova6Alexandr Gzgzyan7Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaWe report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects were observed; all cases resulted in pregnancy and subsequent life births. In order to be given an adequate efficient treatment, women with recurrent implantation failure should be suspected for autoimmune factor of infertility and its possible association with anti-hCG autoimmunity.http://dx.doi.org/10.1155/2016/4391537
collection DOAJ
language English
format Article
sources DOAJ
author Valeria Muller
Ksenia Ob’edkova
Inna Krikheli
Igor Kogan
Irina Fedorova
Elena Lesik
Evgenia Komarova
Alexandr Gzgzyan
spellingShingle Valeria Muller
Ksenia Ob’edkova
Inna Krikheli
Igor Kogan
Irina Fedorova
Elena Lesik
Evgenia Komarova
Alexandr Gzgzyan
Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases
Case Reports in Immunology
author_facet Valeria Muller
Ksenia Ob’edkova
Inna Krikheli
Igor Kogan
Irina Fedorova
Elena Lesik
Evgenia Komarova
Alexandr Gzgzyan
author_sort Valeria Muller
title Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases
title_short Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases
title_full Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases
title_fullStr Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases
title_full_unstemmed Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases
title_sort successful pregnancy outcome in women with recurrent ivf failure and anti-hcg autoimmunity: a report of three cases
publisher Hindawi Limited
series Case Reports in Immunology
issn 2090-6609
2090-6617
publishDate 2016-01-01
description We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects were observed; all cases resulted in pregnancy and subsequent life births. In order to be given an adequate efficient treatment, women with recurrent implantation failure should be suspected for autoimmune factor of infertility and its possible association with anti-hCG autoimmunity.
url http://dx.doi.org/10.1155/2016/4391537
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AT innakrikheli successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases
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