Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin

Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin

Tuberous sclerosis complex (TSC) is a genetic disorder characterized by the development of hamartomas in multiple organs. Neurological manifestation includes cortical dysplasia, epilepsy, and cognitive deficits such as mental impairment and autism. We measured the impact of TSC2-GAP mutations on cog...

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Bibliographic Details
Main Authors: Itzamarie Chévere-Torres, Jordan M. Maki, Emanuela Santini, Eric Klann
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Neurobiology of Disease
Subjects:
Tuberous sclerosis complex
Autism
TSC2
GAP domain
mTORC1
Social interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002543

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