Intracerebral Hemorrhage: Blood Components and Neurotoxicity

Intracerebral hemorrhage (ICH) is a subtype of stroke which is associated with the highest mortality and morbidity rates of all strokes. Although it is a major public health problem, there is no effective treatment for ICH. As a consequence of ICH, various blood components accumulate in the brain pa...

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Main Authors:	Neha Madangarli, Frederick Bonsack, Rajaneekar Dasari, Sangeetha Sukumari–Ramesh
Format:	Article
Language:	English
Published:	MDPI AG 2019-11-01
Series:	Brain Sciences
Subjects:	ich hemin thrombin hemoglobin iron
Online Access:	https://www.mdpi.com/2076-3425/9/11/316

id	doaj-19c1e2df508e429992cc8c39b6a4eaea
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spelling	doaj-19c1e2df508e429992cc8c39b6a4eaea2020-11-25T01:23:20ZengMDPI AGBrain Sciences2076-34252019-11-0191131610.3390/brainsci9110316brainsci9110316Intracerebral Hemorrhage: Blood Components and NeurotoxicityNeha Madangarli0Frederick Bonsack1Rajaneekar Dasari2Sangeetha Sukumari–Ramesh3Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USADepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USADepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USADepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USAIntracerebral hemorrhage (ICH) is a subtype of stroke which is associated with the highest mortality and morbidity rates of all strokes. Although it is a major public health problem, there is no effective treatment for ICH. As a consequence of ICH, various blood components accumulate in the brain parenchyma and are responsible for much of the secondary brain damage and ICH-induced neurological deficits. Therefore, the strategies that could attenuate the blood component-induced neurotoxicity and improve hematoma resolution are highly needed. The present article provides an overview of blood-induced brain injury after ICH and emphasizes the need to conduct further studies elucidating the mechanisms of hematoma resolution after ICH.https://www.mdpi.com/2076-3425/9/11/316ichheminthrombinhemoglobiniron
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Neha Madangarli Frederick Bonsack Rajaneekar Dasari Sangeetha Sukumari–Ramesh
spellingShingle	Neha Madangarli Frederick Bonsack Rajaneekar Dasari Sangeetha Sukumari–Ramesh Intracerebral Hemorrhage: Blood Components and Neurotoxicity Brain Sciences ich hemin thrombin hemoglobin iron
author_facet	Neha Madangarli Frederick Bonsack Rajaneekar Dasari Sangeetha Sukumari–Ramesh
author_sort	Neha Madangarli
title	Intracerebral Hemorrhage: Blood Components and Neurotoxicity
title_short	Intracerebral Hemorrhage: Blood Components and Neurotoxicity
title_full	Intracerebral Hemorrhage: Blood Components and Neurotoxicity
title_fullStr	Intracerebral Hemorrhage: Blood Components and Neurotoxicity
title_full_unstemmed	Intracerebral Hemorrhage: Blood Components and Neurotoxicity
title_sort	intracerebral hemorrhage: blood components and neurotoxicity
publisher	MDPI AG
series	Brain Sciences
issn	2076-3425
publishDate	2019-11-01
description	Intracerebral hemorrhage (ICH) is a subtype of stroke which is associated with the highest mortality and morbidity rates of all strokes. Although it is a major public health problem, there is no effective treatment for ICH. As a consequence of ICH, various blood components accumulate in the brain parenchyma and are responsible for much of the secondary brain damage and ICH-induced neurological deficits. Therefore, the strategies that could attenuate the blood component-induced neurotoxicity and improve hematoma resolution are highly needed. The present article provides an overview of blood-induced brain injury after ICH and emphasizes the need to conduct further studies elucidating the mechanisms of hematoma resolution after ICH.
topic	ich hemin thrombin hemoglobin iron
url	https://www.mdpi.com/2076-3425/9/11/316
work_keys_str_mv	AT nehamadangarli intracerebralhemorrhagebloodcomponentsandneurotoxicity AT frederickbonsack intracerebralhemorrhagebloodcomponentsandneurotoxicity AT rajaneekardasari intracerebralhemorrhagebloodcomponentsandneurotoxicity AT sangeethasukumariramesh intracerebralhemorrhagebloodcomponentsandneurotoxicity
_version_	1725122827059724288

Intracerebral Hemorrhage: Blood Components and Neurotoxicity

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