Susceptibility to superhelically driven DNA duplex destabilization: a highly conserved property of yeast replication origins.
Strand separation is obligatory for several DNA functions, including replication. However, local DNA properties such as A+T content or thermodynamic stability alone do not determine the susceptibility to this transition in vivo. Rather, superhelical stresses provide long-range coupling among the tra...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-06-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://dx.doi.org/10.1371/journal.pcbi.0010007 |