Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis.

Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis.

BRIP1 is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast cancer susceptibility protein BRCA1 and plays an important role in BRCA1-dependent DNA repair and DNA damage-induced checkpoint control. Recent studies implicate BRIP1 as a moderate/low-penetrance breast ca...

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Bibliographic Details
Main Authors: Kazuhiro Daino, Tatsuhiko Imaoka, Takamitsu Morioka, Shusuke Tani, Daisuke Iizuka, Mayumi Nishimura, Yoshiya Shimada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3765252?pdf=render

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http://europepmc.org/articles/PMC3765252?pdf=render

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