Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targ...

Full description

Bibliographic Details
Main Authors:	Takeharu Sakamoto, Yuya Fukui, Yasumitsu Kondoh, Kaori Honda, Takeshi Shimizu, Toshiro Hara, Tetsuro Hayashi, Yurika Saitoh, Yoshinori Murakami, Jun-ichiro Inoue, Shuichi Kaneko, Hiroyuki Osada, Motoharu Seiki
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-10-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-02701-1

id	doaj-19aa786f0153417ab843292a86a3abc2
record_format	Article
spelling	doaj-19aa786f0153417ab843292a86a3abc22021-10-10T11:13:13ZengNature Publishing GroupCommunications Biology2399-36422021-10-014111510.1038/s42003-021-02701-1Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shockTakeharu Sakamoto0Yuya Fukui1Yasumitsu Kondoh2Kaori Honda3Takeshi Shimizu4Toshiro Hara5Tetsuro Hayashi6Yurika Saitoh7Yoshinori Murakami8Jun-ichiro Inoue9Shuichi Kaneko10Hiroyuki Osada11Motoharu Seiki12Department of Cancer Biology, Institute of Biomedical Science, Kansai Medical UniversityDepartment of System Biology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa UniversityChemical Biology Research Group, RIKEN Center for Sustainable Resource ScienceChemical Biology Research Group, RIKEN Center for Sustainable Resource ScienceChemical Biology Research Group, RIKEN Center for Sustainable Resource ScienceDivision of Cancer Cell Research, Institute of Medical Science, The University of TokyoDivision of Molecular Pathology, Institute of Medical Science, The University of TokyoCenter for Medical Education, Teikyo University of ScienceDivision of Molecular Pathology, Institute of Medical Science, The University of TokyoDivision of Cellular and Molecular Biology, The Institute of Medical Science, The University of TokyoDepartment of System Biology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa UniversityChemical Biology Research Group, RIKEN Center for Sustainable Resource ScienceDivision of Cancer Cell Research, Institute of Medical Science, The University of TokyoSakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targeted therapies for cancer and inflammatory diseases that avoid severe adverse effects.https://doi.org/10.1038/s42003-021-02701-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Takeharu Sakamoto Yuya Fukui Yasumitsu Kondoh Kaori Honda Takeshi Shimizu Toshiro Hara Tetsuro Hayashi Yurika Saitoh Yoshinori Murakami Jun-ichiro Inoue Shuichi Kaneko Hiroyuki Osada Motoharu Seiki
spellingShingle	Takeharu Sakamoto Yuya Fukui Yasumitsu Kondoh Kaori Honda Takeshi Shimizu Toshiro Hara Tetsuro Hayashi Yurika Saitoh Yoshinori Murakami Jun-ichiro Inoue Shuichi Kaneko Hiroyuki Osada Motoharu Seiki Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock Communications Biology
author_facet	Takeharu Sakamoto Yuya Fukui Yasumitsu Kondoh Kaori Honda Takeshi Shimizu Toshiro Hara Tetsuro Hayashi Yurika Saitoh Yoshinori Murakami Jun-ichiro Inoue Shuichi Kaneko Hiroyuki Osada Motoharu Seiki
author_sort	Takeharu Sakamoto
title	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_short	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_full	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_fullStr	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_full_unstemmed	Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
title_sort	pharmacological inhibition of mint3 attenuates tumour growth, metastasis, and endotoxic shock
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-10-01
description	Sakomoto et al. identify naphthofluorescein as a mint3 inhibitor that disrupts the Mint3–FIH-1 interaction and attenuates HIF-1 activity. In vivo experiments in mice reveal a reduction in tumor growth with attenuated inflammatory cytokine production and endotoxic shock, presenting an option for targeted therapies for cancer and inflammatory diseases that avoid severe adverse effects.
url	https://doi.org/10.1038/s42003-021-02701-1
work_keys_str_mv	AT takeharusakamoto pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT yuyafukui pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT yasumitsukondoh pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT kaorihonda pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT takeshishimizu pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT toshirohara pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT tetsurohayashi pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT yurikasaitoh pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT yoshinorimurakami pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT junichiroinoue pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT shuichikaneko pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT hiroyukiosada pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock AT motoharuseiki pharmacologicalinhibitionofmint3attenuatestumourgrowthmetastasisandendotoxicshock
_version_	1716829881699926016

Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock

Similar Items