Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A

Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A

Abstract Background New therapeutic drugs are urgently needed against visceral leishmaniasis because current drugs, such as pentavalent antimonials and miltefosine, produce severe side effects and development of resistance. Whether cyclosporine A (CsA) and its derivatives can be used as therapeutic...

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Bibliographic Details
Main Authors: Zhi-Wan Zheng, Jiao Li, Han Chen, Jin-Lei He, Qi-Wei Chen, Jian-Hui Zhang, Qi Zhou, Da-Li Chen, Jian-Ping Chen
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Parasites & Vectors
Subjects:
Cyclosporine A
Dihydrocyclosporin A
Cyclophilin A
Visceral leishmaniasis
Online Access:http://link.springer.com/article/10.1186/s13071-020-3958-x

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