Late-onset isavuconazole-induced liver injury

Late-onset isavuconazole-induced liver injury

Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking. We report a case of late-onset DILI occurring after 11 months of isavuconazole therapy in a 55-year old man of Angolan desc...

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Main Authors: Felix Bongomin, Isabel Rodriguez-Goncer, Carol Lorden, Akaninyene Otu, Rohit Bazaz
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Medical Mycology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211753918300836
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spelling doaj-199f52de98f34c399d7743b1d79d8de32020-11-25T04:00:34ZengElsevierMedical Mycology Case Reports2211-75392018-12-01221113Late-onset isavuconazole-induced liver injuryFelix Bongomin0Isabel Rodriguez-Goncer1Carol Lorden2Akaninyene Otu3Rohit Bazaz4The National Aspergillosis Centre, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK; Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK; Corresponding author at: The National Aspergillosis Centre, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK.The National Aspergillosis Centre, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKThe National Aspergillosis Centre, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKThe National Aspergillosis Centre, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKThe National Aspergillosis Centre, ECMM Centre of Excellence in Clinical and Laboratory Mycology and Clinical Studies, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UKAntifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking. We report a case of late-onset DILI occurring after 11 months of isavuconazole therapy in a 55-year old man of Angolan descent on long-term antifungal therapy for the management of chronic pulmonary aspergillosis complicating previously treated pulmonary tuberculosis. The DILI could be described as idiosyncratic as it was not associated with high isavuconazole serum levels and his liver function tests returned to normal following treatment discontinuation. Keywords: Isavuconazole, Chronic pulmonary aspergillosis, Drug-induced liver injury, Late-onsethttp://www.sciencedirect.com/science/article/pii/S2211753918300836
collection DOAJ
language English
format Article
sources DOAJ
author Felix Bongomin
Isabel Rodriguez-Goncer
Carol Lorden
Akaninyene Otu
Rohit Bazaz
spellingShingle Felix Bongomin
Isabel Rodriguez-Goncer
Carol Lorden
Akaninyene Otu
Rohit Bazaz
Late-onset isavuconazole-induced liver injury
Medical Mycology Case Reports
author_facet Felix Bongomin
Isabel Rodriguez-Goncer
Carol Lorden
Akaninyene Otu
Rohit Bazaz
author_sort Felix Bongomin
title Late-onset isavuconazole-induced liver injury
title_short Late-onset isavuconazole-induced liver injury
title_full Late-onset isavuconazole-induced liver injury
title_fullStr Late-onset isavuconazole-induced liver injury
title_full_unstemmed Late-onset isavuconazole-induced liver injury
title_sort late-onset isavuconazole-induced liver injury
publisher Elsevier
series Medical Mycology Case Reports
issn 2211-7539
publishDate 2018-12-01
description Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking. We report a case of late-onset DILI occurring after 11 months of isavuconazole therapy in a 55-year old man of Angolan descent on long-term antifungal therapy for the management of chronic pulmonary aspergillosis complicating previously treated pulmonary tuberculosis. The DILI could be described as idiosyncratic as it was not associated with high isavuconazole serum levels and his liver function tests returned to normal following treatment discontinuation. Keywords: Isavuconazole, Chronic pulmonary aspergillosis, Drug-induced liver injury, Late-onset
url http://www.sciencedirect.com/science/article/pii/S2211753918300836
work_keys_str_mv AT felixbongomin lateonsetisavuconazoleinducedliverinjury
AT isabelrodriguezgoncer lateonsetisavuconazoleinducedliverinjury
AT carollorden lateonsetisavuconazoleinducedliverinjury
AT akaninyeneotu lateonsetisavuconazoleinducedliverinjury
AT rohitbazaz lateonsetisavuconazoleinducedliverinjury
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