Dengue virus infection-enhancement activity in neutralizing antibodies of healthy adults before dengue season as determined by using FcγR-expressing cells

Dengue virus infection-enhancement activity in neutralizing antibodies of healthy adults before dengue season as determined by using FcγR-expressing cells

Abstract Background Antibodies are critical responses to protect the host from dengue virus(DENV) infection. Antibodies target DENV by two pathologic mechanisms: virus neutralization and infection enhancement. In dengue patients, the absence of neutralizing activity in the presence of FcγR implies t...

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Bibliographic Details
Main Authors: Minh Huong Phu Ly, Meng Ling Moi, Thi Bich Hau Vu, Mya Myat Ngwe Tun, Todd Saunders, Cam Nhat Nguyen, Anh Kieu Thi Nguyen, Hung Manh Nguyen, Than Huu Dao, Do Quyen Pham, Thi Thu Thuy Nguyen, Thi Quynh Mai Le, Futoshi Hasebe, Kouichi Morita
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Infectious Diseases
Subjects:
Dengue virus (DENV)
Dengue virus neutralizing antibody
Primary DENV infection
Secondary DENV infection
Monotypic, heterotypic immune response
Online Access:http://link.springer.com/article/10.1186/s12879-017-2894-7

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