Antiepileptic Stiripentol May Influence Bones

Bone structure abnormalities are increasingly observed in patients chronically treated with antiepileptic drugs (AEDs). The majority of the available data concern older conventional AEDs, while the amount of information regarding newer AEDs, including stiripentol, is limited. The aim of the study wa...

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Main Authors: Agnieszka Matuszewska, Beata Nowak, Anna Nikodem, Anna Merwid-Ląd, Benita Wiatrak, Tomasz Tomkalski, Diana Jędrzejuk, Ewa Szeląg, Tomasz Sozański, Maciej Danielewski, Paulina Jawień, Ireneusz Ceremuga, Marta Szandruk-Bender, Marek Bolanowski, Jarosław Filipiak, Adam Szeląg
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/13/7162
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spelling doaj-199c64e789504bd6b8fba1d0f64e20252021-07-15T15:38:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-01227162716210.3390/ijms22137162Antiepileptic Stiripentol May Influence BonesAgnieszka Matuszewska0Beata Nowak1Anna Nikodem2Anna Merwid-Ląd3Benita Wiatrak4Tomasz Tomkalski5Diana Jędrzejuk6Ewa Szeląg7Tomasz Sozański8Maciej Danielewski9Paulina Jawień10Ireneusz Ceremuga11Marta Szandruk-Bender12Marek Bolanowski13Jarosław Filipiak14Adam Szeląg15Department of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Mechanics, Materials and Biomedical Engineering, Wroclaw University of Science and Technology, ul. Ignacego Łukasiewicza 7/9, 50-371 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Tadeusz Marciniak Lower Silesia Specialist Hospital—Centre for Medical Emergency, ul. Gen. Augusta Emila Fieldorfa 2, 54-049 Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, wyb. Ludwika Pasteura 4, 50-367 Wrocław, PolandDepartment of Maxillofacial Orthopedics and Orthodontics Institute, Wroclaw University of Science and Technology, ul. Krakowska 26, 50-425 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Medical Biochemistry, Wroclaw Medical University, ul. Tytusa Chałubińskiego 10, 50-368 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, wyb. Ludwika Pasteura 4, 50-367 Wrocław, PolandDepartment of Mechanics, Materials and Biomedical Engineering, Wroclaw University of Science and Technology, ul. Ignacego Łukasiewicza 7/9, 50-371 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandBone structure abnormalities are increasingly observed in patients chronically treated with antiepileptic drugs (AEDs). The majority of the available data concern older conventional AEDs, while the amount of information regarding newer AEDs, including stiripentol, is limited. The aim of the study was to assess the effect of stiripentol on bones. For 24 weeks, male Wistar rats, received 0.9% sodium chloride (control group) or stiripentol (200 mg/kg/day) (STP group). In the 16th week of the study, we detected lower serum PINP levels in the STP group compared to the control group. In the 24th week, a statistically significant lower 1,25-dihydroxyvitamin D<sub>3</sub> level, higher inorganic phosphate level and higher neutrophil gelatinase-associated lipocalin (NGAL) levels in serum were found in the STP group compared to the control. Micro X-ray computed tomography of the tibias demonstrated lower bone volume fraction, lower trabecular thickness, higher trabecular pattern factor and a higher structure model index in the stiripentol group. Considering the results of this experiment on rats which suggests that long-term administration of stiripentol may impair the cancellous bone microarchitecture, further prospective human studies seem to be justified. However, monitoring plasma vitamin D, calcium, inorganic phosphate and kidney function in patients on long-term stiripentol therapy may be suggested.https://www.mdpi.com/1422-0067/22/13/7162antiepileptic drugbonecomputed tomographystiripentolvitamin D
collection DOAJ
language English
format Article
sources DOAJ
author Agnieszka Matuszewska
Beata Nowak
Anna Nikodem
Anna Merwid-Ląd
Benita Wiatrak
Tomasz Tomkalski
Diana Jędrzejuk
Ewa Szeląg
Tomasz Sozański
Maciej Danielewski
Paulina Jawień
Ireneusz Ceremuga
Marta Szandruk-Bender
Marek Bolanowski
Jarosław Filipiak
Adam Szeląg
spellingShingle Agnieszka Matuszewska
Beata Nowak
Anna Nikodem
Anna Merwid-Ląd
Benita Wiatrak
Tomasz Tomkalski
Diana Jędrzejuk
Ewa Szeląg
Tomasz Sozański
Maciej Danielewski
Paulina Jawień
Ireneusz Ceremuga
Marta Szandruk-Bender
Marek Bolanowski
Jarosław Filipiak
Adam Szeląg
Antiepileptic Stiripentol May Influence Bones
International Journal of Molecular Sciences
antiepileptic drug
bone
computed tomography
stiripentol
vitamin D
author_facet Agnieszka Matuszewska
Beata Nowak
Anna Nikodem
Anna Merwid-Ląd
Benita Wiatrak
Tomasz Tomkalski
Diana Jędrzejuk
Ewa Szeląg
Tomasz Sozański
Maciej Danielewski
Paulina Jawień
Ireneusz Ceremuga
Marta Szandruk-Bender
Marek Bolanowski
Jarosław Filipiak
Adam Szeląg
author_sort Agnieszka Matuszewska
title Antiepileptic Stiripentol May Influence Bones
title_short Antiepileptic Stiripentol May Influence Bones
title_full Antiepileptic Stiripentol May Influence Bones
title_fullStr Antiepileptic Stiripentol May Influence Bones
title_full_unstemmed Antiepileptic Stiripentol May Influence Bones
title_sort antiepileptic stiripentol may influence bones
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-07-01
description Bone structure abnormalities are increasingly observed in patients chronically treated with antiepileptic drugs (AEDs). The majority of the available data concern older conventional AEDs, while the amount of information regarding newer AEDs, including stiripentol, is limited. The aim of the study was to assess the effect of stiripentol on bones. For 24 weeks, male Wistar rats, received 0.9% sodium chloride (control group) or stiripentol (200 mg/kg/day) (STP group). In the 16th week of the study, we detected lower serum PINP levels in the STP group compared to the control group. In the 24th week, a statistically significant lower 1,25-dihydroxyvitamin D<sub>3</sub> level, higher inorganic phosphate level and higher neutrophil gelatinase-associated lipocalin (NGAL) levels in serum were found in the STP group compared to the control. Micro X-ray computed tomography of the tibias demonstrated lower bone volume fraction, lower trabecular thickness, higher trabecular pattern factor and a higher structure model index in the stiripentol group. Considering the results of this experiment on rats which suggests that long-term administration of stiripentol may impair the cancellous bone microarchitecture, further prospective human studies seem to be justified. However, monitoring plasma vitamin D, calcium, inorganic phosphate and kidney function in patients on long-term stiripentol therapy may be suggested.
topic antiepileptic drug
bone
computed tomography
stiripentol
vitamin D
url https://www.mdpi.com/1422-0067/22/13/7162
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