Antiepileptic Stiripentol May Influence Bones
Bone structure abnormalities are increasingly observed in patients chronically treated with antiepileptic drugs (AEDs). The majority of the available data concern older conventional AEDs, while the amount of information regarding newer AEDs, including stiripentol, is limited. The aim of the study wa...
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doaj-199c64e789504bd6b8fba1d0f64e20252021-07-15T15:38:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-01227162716210.3390/ijms22137162Antiepileptic Stiripentol May Influence BonesAgnieszka Matuszewska0Beata Nowak1Anna Nikodem2Anna Merwid-Ląd3Benita Wiatrak4Tomasz Tomkalski5Diana Jędrzejuk6Ewa Szeląg7Tomasz Sozański8Maciej Danielewski9Paulina Jawień10Ireneusz Ceremuga11Marta Szandruk-Bender12Marek Bolanowski13Jarosław Filipiak14Adam Szeląg15Department of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Mechanics, Materials and Biomedical Engineering, Wroclaw University of Science and Technology, ul. Ignacego Łukasiewicza 7/9, 50-371 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Endocrinology, Diabetology and Internal Medicine, Tadeusz Marciniak Lower Silesia Specialist Hospital—Centre for Medical Emergency, ul. Gen. Augusta Emila Fieldorfa 2, 54-049 Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, wyb. Ludwika Pasteura 4, 50-367 Wrocław, PolandDepartment of Maxillofacial Orthopedics and Orthodontics Institute, Wroclaw University of Science and Technology, ul. Krakowska 26, 50-425 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Medical Biochemistry, Wroclaw Medical University, ul. Tytusa Chałubińskiego 10, 50-368 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandDepartment of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, wyb. Ludwika Pasteura 4, 50-367 Wrocław, PolandDepartment of Mechanics, Materials and Biomedical Engineering, Wroclaw University of Science and Technology, ul. Ignacego Łukasiewicza 7/9, 50-371 Wrocław, PolandDepartment of Pharmacology, Wroclaw Medical University, ul. Jana Mikulicza-Radeckiego 2, 50-345 Wrocław, PolandBone structure abnormalities are increasingly observed in patients chronically treated with antiepileptic drugs (AEDs). The majority of the available data concern older conventional AEDs, while the amount of information regarding newer AEDs, including stiripentol, is limited. The aim of the study was to assess the effect of stiripentol on bones. For 24 weeks, male Wistar rats, received 0.9% sodium chloride (control group) or stiripentol (200 mg/kg/day) (STP group). In the 16th week of the study, we detected lower serum PINP levels in the STP group compared to the control group. In the 24th week, a statistically significant lower 1,25-dihydroxyvitamin D<sub>3</sub> level, higher inorganic phosphate level and higher neutrophil gelatinase-associated lipocalin (NGAL) levels in serum were found in the STP group compared to the control. Micro X-ray computed tomography of the tibias demonstrated lower bone volume fraction, lower trabecular thickness, higher trabecular pattern factor and a higher structure model index in the stiripentol group. Considering the results of this experiment on rats which suggests that long-term administration of stiripentol may impair the cancellous bone microarchitecture, further prospective human studies seem to be justified. However, monitoring plasma vitamin D, calcium, inorganic phosphate and kidney function in patients on long-term stiripentol therapy may be suggested.https://www.mdpi.com/1422-0067/22/13/7162antiepileptic drugbonecomputed tomographystiripentolvitamin D |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Agnieszka Matuszewska Beata Nowak Anna Nikodem Anna Merwid-Ląd Benita Wiatrak Tomasz Tomkalski Diana Jędrzejuk Ewa Szeląg Tomasz Sozański Maciej Danielewski Paulina Jawień Ireneusz Ceremuga Marta Szandruk-Bender Marek Bolanowski Jarosław Filipiak Adam Szeląg |
spellingShingle |
Agnieszka Matuszewska Beata Nowak Anna Nikodem Anna Merwid-Ląd Benita Wiatrak Tomasz Tomkalski Diana Jędrzejuk Ewa Szeląg Tomasz Sozański Maciej Danielewski Paulina Jawień Ireneusz Ceremuga Marta Szandruk-Bender Marek Bolanowski Jarosław Filipiak Adam Szeląg Antiepileptic Stiripentol May Influence Bones International Journal of Molecular Sciences antiepileptic drug bone computed tomography stiripentol vitamin D |
author_facet |
Agnieszka Matuszewska Beata Nowak Anna Nikodem Anna Merwid-Ląd Benita Wiatrak Tomasz Tomkalski Diana Jędrzejuk Ewa Szeląg Tomasz Sozański Maciej Danielewski Paulina Jawień Ireneusz Ceremuga Marta Szandruk-Bender Marek Bolanowski Jarosław Filipiak Adam Szeląg |
author_sort |
Agnieszka Matuszewska |
title |
Antiepileptic Stiripentol May Influence Bones |
title_short |
Antiepileptic Stiripentol May Influence Bones |
title_full |
Antiepileptic Stiripentol May Influence Bones |
title_fullStr |
Antiepileptic Stiripentol May Influence Bones |
title_full_unstemmed |
Antiepileptic Stiripentol May Influence Bones |
title_sort |
antiepileptic stiripentol may influence bones |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-07-01 |
description |
Bone structure abnormalities are increasingly observed in patients chronically treated with antiepileptic drugs (AEDs). The majority of the available data concern older conventional AEDs, while the amount of information regarding newer AEDs, including stiripentol, is limited. The aim of the study was to assess the effect of stiripentol on bones. For 24 weeks, male Wistar rats, received 0.9% sodium chloride (control group) or stiripentol (200 mg/kg/day) (STP group). In the 16th week of the study, we detected lower serum PINP levels in the STP group compared to the control group. In the 24th week, a statistically significant lower 1,25-dihydroxyvitamin D<sub>3</sub> level, higher inorganic phosphate level and higher neutrophil gelatinase-associated lipocalin (NGAL) levels in serum were found in the STP group compared to the control. Micro X-ray computed tomography of the tibias demonstrated lower bone volume fraction, lower trabecular thickness, higher trabecular pattern factor and a higher structure model index in the stiripentol group. Considering the results of this experiment on rats which suggests that long-term administration of stiripentol may impair the cancellous bone microarchitecture, further prospective human studies seem to be justified. However, monitoring plasma vitamin D, calcium, inorganic phosphate and kidney function in patients on long-term stiripentol therapy may be suggested. |
topic |
antiepileptic drug bone computed tomography stiripentol vitamin D |
url |
https://www.mdpi.com/1422-0067/22/13/7162 |
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