<it>Drosophila </it>larvae lacking the <it>bcl-2 </it>gene, <it>buffy</it>, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism

<it>Drosophila </it>larvae lacking the <it>bcl-2 </it>gene, <it>buffy</it>, are sensitive to nutrient stress, maintain increased basal target of rapamycin (Tor) signaling and exhibit characteristics of altered basal energy metabolism

<p>Abstract</p> <p>Background</p> <p>B cell lymphoma 2 (Bcl-2) proteins are the central regulators of apoptosis. The two <it>bcl-2 </it>genes in <it>Drosophila </it>modulate the response to stress-induced cell death, but not developmental cell de...

Full description

Bibliographic Details
Main Authors: Monserrate Jessica P, Chen Michelle Y-Y, Brachmann Carrie
Format: Article
Language:English
Published: BMC 2012-07-01
Series:BMC Biology
Subjects:
autophagy
Bcl-2
metabolism
non-apoptotic
nutrient restriction
S6K
starvation
Tor
Online Access:http://www.biomedcentral.com/1741-7007/10/63

Similar Items

Similar Items