Gene Methylation and Silencing of WIF1 Is a Frequent Genetic Abnormality in Mantle Cell Lymphoma

Gene Methylation and Silencing of WIF1 Is a Frequent Genetic Abnormality in Mantle Cell Lymphoma

We have previously shown that the Wnt canonical pathway (WCP) is constitutively active in most cases of mantle cell lymphoma (MCL). Here, we aimed to elucidate the mechanisms underlying this biochemical deregulation. We hypothesized that gene methylation/silencing of WIF1 (Wnt inhibitory factor-1),...

Full description

Bibliographic Details
Main Authors:	Abdulraheem Alshareef, Anthea C. Peters, Pascal Gélébart, Will Chen, Raymond Lai
Format:	Article
Language:	English
Published:	MDPI AG 2021-01-01
Series:	International Journal of Molecular Sciences
Subjects:	mantle cell lymphoma Wnt canonical pathway Wnt inhibitory factor-1 gene methylation
Online Access:	https://www.mdpi.com/1422-0067/22/2/893

Similar Items

Effects of Wnt/β-catenin signaling pathway on the proliferation and invasive growth of cells in mantle cell lymphoma
by: Wen-Di Zhang, et al.
Published: (2018-10-01)

NF-κB signaling and its relevance to the treatment of mantle cell lymphoma
by: Swathi Balaji, et al.
Published: (2018-06-01)

Two cases of systemic mantle cell lymphoma involving the skin
by: Viktoryia Kazlouskaya, et al.
Published: (2016-01-01)

DNA methylation of SFRP1, SFRP2, and WIF1 and prognosis of postoperative colorectal cancer patients
by: Xinyan Liu, et al.
Published: (2019-12-01)

Mantle cell lymphoma
by: V. I. Vorob’ev, et al.
Published: (2020-11-01)

cutaneous manifestation of mantle cell lymphoma
by: avinash kumar singh, et al.
Published: (2014-08-01)

Targeted therapies in mantle cell lymphoma
by: Tucker, Catherine Amanda
Published: (2008)

Targeted therapies in mantle cell lymphoma
by: Tucker, Catherine Amanda
Published: (2008)

Targeted therapies in mantle cell lymphoma
by: Tucker, Catherine Amanda
Published: (2008)

Smoldering mantle cell lymphoma
by: Haige Ye, et al.
Published: (2017-12-01)

Mantle cell lymphoma involving the thyroid gland
by: Georgios N Pongas, et al.
Published: (2021-09-01)

WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts
by: Edyta Działo, et al.
Published: (2019-03-01)

Pulmonary mantle cell lymphoma: a rare manifestation of an uncommon condition
by: Zachary S. DePew, et al.
Published: (2012-02-01)

Multiple lymphomatous polyposis: A presentation for mantle cell lymphoma
by: Cory Gallivan, et al.
Published: (2020-12-01)

Skin manifestation of mantle cell lymphoma – case report and literature review
by: Agnieszka Markiewicz, et al.
Published: (2017-12-01)

Identification of epigenetic biomarkers for diagnosis of nasopharyngeal carcinoma and determination of WIF1 functional relevance
by: Yang, Xuesong, et al.
Published: (2015)

Mantle Cell Lymphoma Presenting as a Subcutaneous Mass of the Right Leg
by: Drew A. Fajardo, et al.
Published: (2020-07-01)

Colonic Mantle Cell Lymphoma with Multiple Lymphomatous Polyposis
by: Rama Nassri, et al.
Published: (2020-01-01)

Mantle Cell Lymphoma Presenting with Acute Bilateral Ophthalmoplegia
by: Yaran Koban, et al.
Published: (2017-08-01)

Emerging Roles of Wnt Ligands in Human Colorectal Cancer
by: Xiaobo Nie, et al.
Published: (2020-08-01)

Differential expression of Wnt inhibitors Dickkopf-1 (Dkk-1) and Wnt inhibitory factor-1 (Wif1) in the regulation of urorectal development
by: Ho, Sze-hang, et al.
Published: (2015)

Chylous Ascites due to Mantle Cell Lymphoma
by: Ricardo Jorge Gonçalves Fernandes, et al.
Published: (2018-04-01)

Wnt9A Induction Linked to Suppression of Human Colorectal Cancer Cell Proliferation
by: Irshad Ali, et al.
Published: (2016-04-01)

Primary gastric mantle cell lymphoma
by: Duska Petranovic, et al.
Published: (2012-01-01)

Cutaneous mantle cell lymphoma: A rare case report
by: Salwa Bano, et al.
Published: (2020-01-01)

Spontaneous regression of mantle cell lymphoma: a report of four cases
by: Haige Ye, et al.
Published: (2018-05-01)

Mantle Cell Lymphoma of Intestine Presenting as Multiple Lymphomatous Polyposis with Intussusception
by: Meena N. Jadhav, et al.
Published: (2015-01-01)

Skin Manifestations associated with Mantle cell Lymphoma: a case report
by: avinash kumar singh, et al.
Published: (2013-02-01)

Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
by: Naotaka Tsutsumi, et al.
Published: (2020-08-01)

Cutaneous lesions as presentation form of mantle cell lymphoma
by: Nayra Merino de Paz, et al.
Published: (2011-12-01)

Recurrent Mantle Cell Lymphoma Presenting as Gastrointestinal Bleeding
by: Rafeeq Ahmed, et al.
Published: (2018-08-01)

A case of langerhans cell histiocytosis associated with mantle cell lymphoma
by: Fatih Demirkan, et al.
Published: (2018-09-01)

Wif1 Inhibits the Growth of Basal Cell Carcinoma
by: Becker, Marco
Published: (2015)

Mantle Cell Lymphoma of the Palatine Tonsil: A Rare Case Report
by: Ranjitha Rao, et al.
Published: (2018-09-01)

Mantle Cell Lymphoma: Effectiveness of Maintenance Ibrutinib – Case Report
by: Danuta Krasowska, et al.
Published: (2020-09-01)

An Eye on the Wnt Inhibitory Factor Wif1
by: Lucia Poggi, et al.
Published: (2018-12-01)

Mantle Cell Lymphoma Presenting as Multiple Lymphomatous Polyposis of the Colon
by: Syed Shafiq, et al.
Published: (2020-06-01)

A clinicopathologic study of mantle cell lymphoma in a single center study in India
by: Gujral S, et al.
Published: (2008-07-01)

Gastrointestinal Perforation after Rituximab Therapy in Mantle Cell Lymphoma: A Case Report
by: Michael Adashek, et al.
Published: (2018-11-01)

Progress in molecular feature of smoldering mantle cell lymphoma
by: Panruo Jiang, et al.
Published: (2021-07-01)

Cannot write session to /tmp/vufind_sessions/sess_jb0sh9h6qqv4aqiqcndchdldrr