Structures of FOX-4 Cephamycinase in Complex withTransition-State Analog Inhibitors

Structures of FOX-4 Cephamycinase in Complex withTransition-State Analog Inhibitors

Boronic acid transition-state analog inhibitors (BATSIs) are partners with β-lactam antibiotics for the treatment of complex bacterial infections. Herein, microbiological, biochemical, and structural findings on four BATSIs with the FOX-4 cephamycinase, a class C β-lactamase that rapidly hydrolyzes...

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Bibliographic Details
Main Authors: Scott T. Lefurgy, Emilia Caselli, Magdalena A. Taracila, Vladimir N. Malashkevich, Beena Biju, Krisztina M. Papp-Wallace, Jeffrey B. Bonanno, Fabio Prati, Steven C. Almo, Robert A. Bonomo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
β-lactam
β-lactamase
cephamycinase
boronic acid
transition-state analog inhibitor
Online Access:https://www.mdpi.com/2218-273X/10/5/671

Internet

https://www.mdpi.com/2218-273X/10/5/671

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