The Oncolytic Activity of Myxoma Virus against Soft Tissue Sarcoma Is Mediated by the Overexpression of Ribonucleotide Reductase

The Oncolytic Activity of Myxoma Virus against Soft Tissue Sarcoma Is Mediated by the Overexpression of Ribonucleotide Reductase

Background: Myxoma virus (MYXV) is an oncolytic poxvirus that lacks the gene for 1 of the subunits of ribonucleotide reductase (RR), a crucial DNA synthesis and repair enzyme. The overexpression of RR has been implicated in the invasiveness of several cancers, including soft tissue sarcomas (STS). T...

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Bibliographic Details
Main Authors:	Yanghee Woo, Susanne G Warner, Rula Geha, Marianne M Stanford, Penelope Decarolis, Masmudur M Rahman, Samuel Singer, Grant McFadden, Yuman Fong
Format:	Article
Language:	English
Published:	SAGE Publishing 2021-02-01
Series:	Clinical Medicine Insights: Oncology
Online Access:	https://doi.org/10.1177/1179554921993069

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