Causal Linkage Between Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Two-Sample Mendelian Randomization Analysis

Causal Linkage Between Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Two-Sample Mendelian Randomization Analysis

BackgroundObservational studies suggest an association between inflammatory bowel disease (IBD) [including ulcerative colitis (UC) and Crohn’s disease (CD)] and Primary sclerosing cholangitis (PSC), but the causal association between the two diseases remains unclear.MethodsWe used two-sample Mendeli...

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Bibliographic Details
Main Authors: Ying Xie, Xuejie Chen, Minzi Deng, Yuhao Sun, Xiaoyan Wang, Jie Chen, Changzheng Yuan, Therese Hesketh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Genetics
Subjects:
inflammatory bowel disease
ulcerative colitis
Crohn’s disease
mendelian randomization
primary sclerosing cholangitis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.649376/full

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