C-Terminal Peptide Modifications Reveal Direct and Indirect Roles of Hedgehog Morphogen Cholesteroylation

C-Terminal Peptide Modifications Reveal Direct and Indirect Roles of Hedgehog Morphogen Cholesteroylation

Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylation during biosynthesis. The current hypothesis is...

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Bibliographic Details
Main Authors: Dominique Manikowski, Philipp Kastl, Sabine Schürmann, Kristina Ehring, Georg Steffes, Petra Jakobs, Kay Grobe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hedgehog
Sonic hedgehog
Drosophila
proteolysis
morphogen
signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.615698/full

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