Histone deacetylase 1 induced by neddylation inhibition contributes to drug resistance in acute myelogenous leukemia

Histone deacetylase 1 induced by neddylation inhibition contributes to drug resistance in acute myelogenous leukemia

Abstract Objective This study aimed to investigate the function and mechanism of neddylation of HDAC1 underlying drug resistance of AML cells. Methods Evaluation experiments of effects of HDAC1 on drug resistance of AML cells were performed with AML cell transfected with constructs overexpressing HD...

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Bibliographic Details
Main Authors: Qiu-yu Lai, Ying-zhi He, Xiong-wen Peng, Xuan Zhou, Dan Liang, Liang Wang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cell Communication and Signaling
Subjects:
Acute myelogenous leukemia
Drug resistance
HDAC1
Neddylation
Ubiquitination
Online Access:http://link.springer.com/article/10.1186/s12964-019-0393-8

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