Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging

Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging

Clinical and preclinical in vivo tracking of extracellular vesicles (EVs) are a crucial tool for the development and optimization of EV-based diagnosis and treatment. EVs have gained interest due to their unique properties that make them excellent candidates for biological applications. Noninvasive...

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Main Authors: Prakash Gangadaran, Chae Moon Hong, Byeong-Cheol Ahn
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2017/9158319
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spelling doaj-193ff222b2814d9fa28d2a321d16316d2020-11-25T01:02:11ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/91583199158319Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular ImagingPrakash Gangadaran0Chae Moon Hong1Byeong-Cheol Ahn2Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu 700-721, Republic of KoreaDepartment of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu 700-721, Republic of KoreaDepartment of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu 700-721, Republic of KoreaClinical and preclinical in vivo tracking of extracellular vesicles (EVs) are a crucial tool for the development and optimization of EV-based diagnosis and treatment. EVs have gained interest due to their unique properties that make them excellent candidates for biological applications. Noninvasive in vivo EV tracking has allowed marked progress towards elucidating the mechanisms and functions of EVs in real time in preclinical and clinical studies. In this review, we summarize several molecular imaging methods that deal with EVs derived from different cells, which have allowed investigations of EV biodistribution, as well as their tracking, delivery, and tumor targeting, to determine their physiological functions and to exploit imaging-derived information for EV-based theranostics.http://dx.doi.org/10.1155/2017/9158319
collection DOAJ
language English
format Article
sources DOAJ
author Prakash Gangadaran
Chae Moon Hong
Byeong-Cheol Ahn
spellingShingle Prakash Gangadaran
Chae Moon Hong
Byeong-Cheol Ahn
Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
BioMed Research International
author_facet Prakash Gangadaran
Chae Moon Hong
Byeong-Cheol Ahn
author_sort Prakash Gangadaran
title Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_short Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_full Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_fullStr Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_full_unstemmed Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging
title_sort current perspectives on in vivo noninvasive tracking of extracellular vesicles with molecular imaging
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2017-01-01
description Clinical and preclinical in vivo tracking of extracellular vesicles (EVs) are a crucial tool for the development and optimization of EV-based diagnosis and treatment. EVs have gained interest due to their unique properties that make them excellent candidates for biological applications. Noninvasive in vivo EV tracking has allowed marked progress towards elucidating the mechanisms and functions of EVs in real time in preclinical and clinical studies. In this review, we summarize several molecular imaging methods that deal with EVs derived from different cells, which have allowed investigations of EV biodistribution, as well as their tracking, delivery, and tumor targeting, to determine their physiological functions and to exploit imaging-derived information for EV-based theranostics.
url http://dx.doi.org/10.1155/2017/9158319
work_keys_str_mv AT prakashgangadaran currentperspectivesoninvivononinvasivetrackingofextracellularvesicleswithmolecularimaging
AT chaemoonhong currentperspectivesoninvivononinvasivetrackingofextracellularvesicleswithmolecularimaging
AT byeongcheolahn currentperspectivesoninvivononinvasivetrackingofextracellularvesicleswithmolecularimaging
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