Task-related Functional Connectivity Dynamics in a Block-designed Visual Experiment
Studying task modulations of brain connectivity using functional magnetic resonance imaging (fMRI) is critical to understand brain functions that support cognitive and affective processes. Existing methods such as psychophysiological interaction (PPI) and dynamic causal modelling (DCM) usually impli...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-09-01
|
Series: | Frontiers in Human Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00543/full |
id |
doaj-193ec4952dd541b6b0c4bc5de3317920 |
---|---|
record_format |
Article |
spelling |
doaj-193ec4952dd541b6b0c4bc5de33179202020-11-25T03:16:24ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-09-01910.3389/fnhum.2015.00543159542Task-related Functional Connectivity Dynamics in a Block-designed Visual ExperimentXin eDi0Zening eFu1Shing Chow eChan2Yeung Sam eHung3Bharat B Biswal4Zhiguo eZhang5Zhiguo eZhang6New Jersey Institute of Technologythe University of Hong Kongthe University of Hong Kongthe University of Hong KongNew Jersey Institute of TechnologyNanyang Technological Universitythe University of Hong KongStudying task modulations of brain connectivity using functional magnetic resonance imaging (fMRI) is critical to understand brain functions that support cognitive and affective processes. Existing methods such as psychophysiological interaction (PPI) and dynamic causal modelling (DCM) usually implicitly assume that the connectivity patterns are stable over a block-designed task with identical stimuli. However, this assumption lacks empirical verification on high-temporal resolution fMRI data with reliable data-driven analysis methods. The present study performed a detailed examination of dynamic changes of functional connectivity (FC) in a simple block-designed visual checkerboard experiment with a sub-second sampling rate (TR = 0.645 s) by estimating time-varying correlation coefficient (TVCC) between BOLD responses of different brain regions. We observed reliable task-related FC changes (i.e., FCs were transiently decreased after task onset and went back to the baseline afterward) among several visual regions of the bilateral middle occipital gyrus (MOG) and the bilateral fusiform gyrus (FuG). Importantly, only the FCs between higher visual regions (MOG) and lower visual regions (FuG) exhibited such dynamic patterns. The results suggested that simply assuming a sustained FC during a task block may be insufficient to capture distinct task-related FC changes. The investigation of FC dynamics in tasks could improve our understanding of condition shifts and the coordination between different activated brain regions.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00543/fullVisual Systemfunctional connectivitysliding windowDynamic connectivitytime-varying correlation coefficient |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin eDi Zening eFu Shing Chow eChan Yeung Sam eHung Bharat B Biswal Zhiguo eZhang Zhiguo eZhang |
spellingShingle |
Xin eDi Zening eFu Shing Chow eChan Yeung Sam eHung Bharat B Biswal Zhiguo eZhang Zhiguo eZhang Task-related Functional Connectivity Dynamics in a Block-designed Visual Experiment Frontiers in Human Neuroscience Visual System functional connectivity sliding window Dynamic connectivity time-varying correlation coefficient |
author_facet |
Xin eDi Zening eFu Shing Chow eChan Yeung Sam eHung Bharat B Biswal Zhiguo eZhang Zhiguo eZhang |
author_sort |
Xin eDi |
title |
Task-related Functional Connectivity Dynamics in a Block-designed Visual Experiment |
title_short |
Task-related Functional Connectivity Dynamics in a Block-designed Visual Experiment |
title_full |
Task-related Functional Connectivity Dynamics in a Block-designed Visual Experiment |
title_fullStr |
Task-related Functional Connectivity Dynamics in a Block-designed Visual Experiment |
title_full_unstemmed |
Task-related Functional Connectivity Dynamics in a Block-designed Visual Experiment |
title_sort |
task-related functional connectivity dynamics in a block-designed visual experiment |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2015-09-01 |
description |
Studying task modulations of brain connectivity using functional magnetic resonance imaging (fMRI) is critical to understand brain functions that support cognitive and affective processes. Existing methods such as psychophysiological interaction (PPI) and dynamic causal modelling (DCM) usually implicitly assume that the connectivity patterns are stable over a block-designed task with identical stimuli. However, this assumption lacks empirical verification on high-temporal resolution fMRI data with reliable data-driven analysis methods. The present study performed a detailed examination of dynamic changes of functional connectivity (FC) in a simple block-designed visual checkerboard experiment with a sub-second sampling rate (TR = 0.645 s) by estimating time-varying correlation coefficient (TVCC) between BOLD responses of different brain regions. We observed reliable task-related FC changes (i.e., FCs were transiently decreased after task onset and went back to the baseline afterward) among several visual regions of the bilateral middle occipital gyrus (MOG) and the bilateral fusiform gyrus (FuG). Importantly, only the FCs between higher visual regions (MOG) and lower visual regions (FuG) exhibited such dynamic patterns. The results suggested that simply assuming a sustained FC during a task block may be insufficient to capture distinct task-related FC changes. The investigation of FC dynamics in tasks could improve our understanding of condition shifts and the coordination between different activated brain regions. |
topic |
Visual System functional connectivity sliding window Dynamic connectivity time-varying correlation coefficient |
url |
http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00543/full |
work_keys_str_mv |
AT xinedi taskrelatedfunctionalconnectivitydynamicsinablockdesignedvisualexperiment AT zeningefu taskrelatedfunctionalconnectivitydynamicsinablockdesignedvisualexperiment AT shingchowechan taskrelatedfunctionalconnectivitydynamicsinablockdesignedvisualexperiment AT yeungsamehung taskrelatedfunctionalconnectivitydynamicsinablockdesignedvisualexperiment AT bharatbbiswal taskrelatedfunctionalconnectivitydynamicsinablockdesignedvisualexperiment AT zhiguoezhang taskrelatedfunctionalconnectivitydynamicsinablockdesignedvisualexperiment AT zhiguoezhang taskrelatedfunctionalconnectivitydynamicsinablockdesignedvisualexperiment |
_version_ |
1724636458863558656 |