CB2 Receptor Activation Inhibits Melanoma Cell Transmigration through the Blood-Brain Barrier

CB2 Receptor Activation Inhibits Melanoma Cell Transmigration through the Blood-Brain Barrier

During parenchymal brain metastasis formation tumor cells need to migrate through cerebral endothelial cells, which form the morphological basis of the blood-brain barrier (BBB). The mechanisms of extravasation of tumor cells are highly uncharacterized, but in some aspects recapitulate the diapedesi...

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Bibliographic Details
Main Authors: János Haskó, Csilla Fazakas, Judit Molnár, Ádám Nyúl-Tóth, Hildegard Herman, Anca Hermenean, Imola Wilhelm, Yuri Persidsky, István A. Krizbai
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:International Journal of Molecular Sciences
Subjects:
blood-brain barrier (BBB)
cerebral metastasis
melanoma
cannabinoid
CB2
Online Access:http://www.mdpi.com/1422-0067/15/5/8063

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