The gut microbiome-bile acid axis in hepatocarcinogenesis

The gut microbiome-bile acid axis in hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related deaths globally, with few effective therapeutic options. Bile acids (BAs) are synthesized from cholesterol in the liver and can be modulated by farnesoid X receptor (FXR) and G-protein...

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Main Authors: Liwei Wu, Jiao Feng, Jingjing Li, Qiang Yu, Jie Ji, Jianye Wu, Weiqi Dai, Chuanyong Guo
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Gut microbiome
Bile acids
Hepatocellular carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220312282
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spelling doaj-191be437bd804550b84e6c3dd653019b2021-05-21T04:19:21ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-01-01133111036The gut microbiome-bile acid axis in hepatocarcinogenesisLiwei Wu0Jiao Feng1Jingjing Li2Qiang Yu3Jie Ji4Jianye Wu5Weiqi Dai6Chuanyong Guo7Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Corresponding author at: Department of Gastroenterology, Putuo People's Hospital, NO. 1291, Jiangning road, Putuo, Shanghai 200060, China.Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China; Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai 200032, China; Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai 200032, China; Shanghai Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200336, China; Corresponding author at: Department of Gastroenterology, Putuo People's Hospital, NO. 1291, Jiangning road, Putuo, Shanghai 200060, China.Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai 200060, China; Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China; Corresponding author at: Department of Gastroenterology, Shanghai Tenth People’s Hospital, NO. 301, Middle Yanchang road, Jing’an, Shanghai 200072, China.Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related deaths globally, with few effective therapeutic options. Bile acids (BAs) are synthesized from cholesterol in the liver and can be modulated by farnesoid X receptor (FXR) and G-protein coupled BA receptor 1 (GPBAR1/TGR5). Alterations in BAs can affect hepatic metabolic homeostasis and contribute to the pathogenesis of liver cancer. Increasing evidence points to the key role of bacterial microbiota in the promotion and development of liver cancer. They are also involved in the regulation of BA synthesis and metabolism. The purpose of this review is to integrate related articles involving gut microbiota, BAs and HCC, and review how the gut microbiota-BA signaling axis can possibly influence the development of HCC.http://www.sciencedirect.com/science/article/pii/S0753332220312282Gut microbiomeBile acidsHepatocellular carcinoma
collection DOAJ
language English
format Article
sources DOAJ
author Liwei Wu
Jiao Feng
Jingjing Li
Qiang Yu
Jie Ji
Jianye Wu
Weiqi Dai
Chuanyong Guo
spellingShingle Liwei Wu
Jiao Feng
Jingjing Li
Qiang Yu
Jie Ji
Jianye Wu
Weiqi Dai
Chuanyong Guo
The gut microbiome-bile acid axis in hepatocarcinogenesis
Biomedicine & Pharmacotherapy
Gut microbiome
Bile acids
Hepatocellular carcinoma
author_facet Liwei Wu
Jiao Feng
Jingjing Li
Qiang Yu
Jie Ji
Jianye Wu
Weiqi Dai
Chuanyong Guo
author_sort Liwei Wu
title The gut microbiome-bile acid axis in hepatocarcinogenesis
title_short The gut microbiome-bile acid axis in hepatocarcinogenesis
title_full The gut microbiome-bile acid axis in hepatocarcinogenesis
title_fullStr The gut microbiome-bile acid axis in hepatocarcinogenesis
title_full_unstemmed The gut microbiome-bile acid axis in hepatocarcinogenesis
title_sort gut microbiome-bile acid axis in hepatocarcinogenesis
publisher Elsevier
series Biomedicine & Pharmacotherapy
issn 0753-3322
publishDate 2021-01-01
description Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related deaths globally, with few effective therapeutic options. Bile acids (BAs) are synthesized from cholesterol in the liver and can be modulated by farnesoid X receptor (FXR) and G-protein coupled BA receptor 1 (GPBAR1/TGR5). Alterations in BAs can affect hepatic metabolic homeostasis and contribute to the pathogenesis of liver cancer. Increasing evidence points to the key role of bacterial microbiota in the promotion and development of liver cancer. They are also involved in the regulation of BA synthesis and metabolism. The purpose of this review is to integrate related articles involving gut microbiota, BAs and HCC, and review how the gut microbiota-BA signaling axis can possibly influence the development of HCC.
topic Gut microbiome
Bile acids
Hepatocellular carcinoma
url http://www.sciencedirect.com/science/article/pii/S0753332220312282
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