Interleukin-27 Early Impacts Leishmania infantum Infection in Mice and Correlates with Active Visceral Disease in Humans

Interleukin-27 Early Impacts Leishmania infantum Infection in Mice and Correlates with Active Visceral Disease in Humans

The complexity of Leishmania-host interactions, one of the main leishmaniasis issues, is yet to be fully understood. We detected elevated IL-27 plasma levels in European patients with active visceral disease caused by Leishmania infantum, which returned to basal levels after successful treatment, su...

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Bibliographic Details
Main Authors: Begoña Pérez-Cabezas, Pedro Cecílio, Ana luisa Robalo, Ricardo Silvestre, Eugenia Carrillo, Javier Moreno, Juan V. San Martín, Rita Vasconcellos, Anabela Cordeiro-da-Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Leishmania infantum
human
mouse models
il-27
Immune Regulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00478/full

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